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2024-11-07 08:55:35 -

Introduction to Sentieon
Sentieon Vision 01.Sentieon Vision Sentieon is dedicated to solving the bottleneck of speed and accuracy in bioinformatics data analysis, through the deep optimization of algorithms and enterprise-level software engineering, to significantly improve the efficiency, accuracy and reliability of NGS data processing. Sentieon provides software solutions to partners and research institutions in...

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2024-12-17 02:26:06 -

Sentieon | Application Tutorial: Accelerating Custom Algorithms Using the Sentieon Python API Engine
Background All modules in the Sentieon suite are several times to dozens of times faster than their corresponding open-source software. While using these modules, users sometimes hope that the Sentieon team can help accelerate their custom-developed software. To help these users enjoy the speed of Sentieon modules in their own software, we have developed a Python API system to meet the needs...

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2024-12-06 02:37:45 -

Sentieon | Application Tutorial: Germline Variant Detection Analysis of HiFi Long-Read Data Using DNAscope
Introduction This document describes germline variant calling for PacBio® HiFi data using Sentieon® DNAscope. PacBio® HiFi technology produces high-quality long reads with quality scores above Q20 and average lengths between 10-25kb. These accurate long reads enable precise variant detection in genomic repeat regions that are challenging for short-read and noisy long-read methods....

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2025-01-15 05:49:31 -

Sentieon | Application Tutorial: TNscope® Using Machine Learning Models for Somatic Variant Discovery with Matched Normal Samples;
Using Machine Learning Models in TNscope® Objectives of Machine Learning Models in TNscope® TNscope® allows you to use machine learning models for variant filtering to improve the accuracy of results. The machine learning model approach is described in https://www.biorxiv.org/content/early/2018/01/19/250647, and TNscope® uses a series of sensitive settings to detect more...

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